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Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy

11 Feb 2017

Abstract excerpt

Receptor tyrosine kinases (RTKs) belong to a family of transmembrane receptors that display tyrosine kinase activity and trigger the activation of downstream signalling pathways mainly involved in cell proliferation and survival. RTK amplification or somatic mutations leading to their constitutive activation and oncogenic properties have been reported in various tumour types. Numerous RTK-targeted therapies have...

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PMID: 28208660
DOI: 10.3390/ijms18020383

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