Article
Association between cytochrome P450 3A5 polymorphism and the lung function in Saskatchewan grain workers.
Pharmacogenetics and genomics - 1 Jun 2008
Seo Takayuki, Pahwa Punam, McDuffie Helen H, Yurube Keigo, Egoshi Masayoshi, Umemoto Yuichiro, Ghosh Sunita, Fukushima Yumi, Nakagawa Kazuko
Abstract excerpt
OBJECTIVE: The activity of the enzymes that metabolize tobacco smoke may affect the susceptibility to chronic obstructive pulmonary disease (COPD). Cytochrome P450 (CYP) 3A5 is expressed selectively over CYP3A4 in human lung, but the association between the CYP3A5 polymorphisms and the airway injury is unknown. METHODS: Two hundred and six male Saskatchewan grain workers participated in this longitudinal study,...
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