5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities.

doi:10.1016/j.jclinane.2010.11.003

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Article

5 HT(3)-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities.

Journal of clinical anesthesia - 1 Jun 2011

Quraishi Sadeq A, Schuler Gregg H, Janicki Piotr K

Abstract excerpt

STUDY OBJECTIVE: To investigate whether a common single nucleotide polymorphism (SNP), rs10494366, is associated with significant prolongation of the QTc interval following administration of 5-HT(3)-receptor antagonists in the perioperative setting. DESIGN: Post-hoc analysis of deoxyribonucleic acid (DNA) samples and electrocardiographic (ECG) data from an established perioperative genomics database. SETTING:...

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PMID: 21663814
DOI: 10.1016/j.jclinane.2010.11.003

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