Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney disease.

doi:10.1161/ATVBAHA.114.303211

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2014

Holden Rachel M, Booth Sarah L, Tuttle Angie, James Paula D, Morton Alexander R, Hopman Wilma M, Nolan Robert Louis, Garland Jocelyn S

Abstract excerpt

OBJECTIVE: Sequence variations in the gene(s) encoding vitamin K epoxide reductase complex subunit 1 (VKORC1), the enzyme target of warfarin, have been associated with increased cardiovascular disease in the general population. Coronary artery calcification (CAC) is a prevalent form of cardiovascular disease in chronic kidney disease. We tested the hypothesis that the VKORC1 rs8050894 CC genotype would be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Odds Ratio

Share to Renal Insufficiency, Chronic

Share to Severity of Illness Index

Share to Time Factors

Share to Vascular Calcification

Share to Vitamin K Epoxide Reductases

Source

Open in PubMed

Identifiers

PMID: 24855061
DOI: 10.1161/ATVBAHA.114.303211

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney disease.PMID 24855061Read ↗

VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.Semantic proximity Read ↗

VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification.Semantic proximity Read ↗

VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).Semantic proximity Read ↗

Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: the Rotterdam Study.Semantic proximity Read ↗

Vascular calcification in chronic kidney disease associated with pathogenic variants in ABCC6.Semantic proximity Read ↗

Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.Semantic proximity Read ↗

Epidermal Growth Factor Receptor Inhibition Prevents Caveolin-1-dependent Calcifying Extracellular Vesicle BiogenesisSemantic proximity Read ↗

Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).Semantic proximity Read ↗

Missense mutation of VKORC1 leads to medial arterial calcification in rats.Semantic proximity Read ↗

CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events.Semantic proximity Read ↗

Calcium-sensing receptor gene polymorphisms and cardiac valvular calcification in patients with chronic renal failure: a pilot study.Semantic proximity Read ↗

Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.