Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.

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Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.

Thrombosis and haemostasis - 1 Jun 2007

Watzka Matthias, Nebel Almut, El Mokhtari Nour Eddine, Ivandic Boris, Müller Jens, Schreiber Stefan, Oldenburg Johannes

Abstract excerpt

Recently, the C-allele of polymorphism rs2359612 (VKORC1: c.283+837C>T) in the VKORC1 gene has been reported to represent a major risk factor for coronary heart disease (CHD), stroke, and aortic dissection in Chinese patients. VKOR activity itself is the rate-limiting step in gamma-carboxylation of vitamin K-dependent coagulation factors (factors II, VII, IX, X, protein C, S, and Z) and proteins of calcium...

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PMID: 17549303

Genes

VKORC1

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