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Article

Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Ramos-Amaya Ana, Rodríguez-Bayona Beatriz, López-Blanco Rubén, Andújar Eloisa, Pérez-Alegre Mónica, Campos-Caro Antonio, Brieva José A

Abstract excerpt

Human circulating Ag-induced plasma cells (PCs) contain a high proportion of cycling cells. This study reveals that these PCs spontaneously proliferate in culture during 72 h, as determined by BrdU-uptake detection. Transcriptome analysis indicates that, in comparison with tonsil and bone marrow (BM) PCs, these PCs distinctively upregulate genes involved in cell division. Blood PC proliferation occurs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25548228
DOI: 10.4049/jimmunol.1402231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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