Article
Energy balance alters dunning R3327-H prostate tumor architecture, androgen receptor expression, and nuclear morphometry in rats.
The Prostate - 15 Jun 2006
Liao Zhiming, Wang Shihua, Wiegers Brandy S, Clinton Steven K
Abstract excerpt
BACKGROUND: We hypothesize that diet or energy restriction may alter prostate tumor architecture and nuclear morphometry in a manner predictive of indolent biology. METHODS: Adult male rats bearing the Dunning R3327-H tumor were provided free-access to the AIN76 diet or 30% diet/energy restriction for 16 weeks. Tumor tissue was harvested and stained for biomarker evaluation by quantitative digital image analysis....
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