Article
Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors.
Neoplasia (New York, N.Y.) - 1 Jan 2007
Zechmann Christian M, Woenne Eva C, Brix Gunnar, Radzwill Nicole, Ilg Martin, Bachert Peter, Peschke Peter, Kirsch Stefan, Kauczor Hans-Ulrich, Delorme Stefan, Semmler Wolfhard, Kiessling Fabian
Abstract excerpt
In prostate cancers (PCa), the formation of malignant stroma may substantially influence tumor phenotype and aggressiveness. Thus, the impact of the orthotopic and subcutaneous implantations of hormone-sensitive (H), hormone-insensitive (HI), and anaplastic (AT1) Dunning PCa in rats on growth, microcirculation, and metabolism was investigated. For this purpose, dynamic contrast-enhanced magnetic resonance imaging...
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