Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exposure to maternal obesogenic diet worsens some but not all pre-cancer phenotypes in a murine genetic model of prostate cancer.

PloS one - 1 Jan 2017

Okeyo-Owuor Theresa, Benesh Emily, Bibbey Scott, Reid Michaela, Halabi Jacques, Sutcliffe Siobhan, Moley Kelle

Abstract excerpt

Prostate cancer research has been predominantly focused on adult exposures and risk factors. However, because the prostate develops during gestation and early life, exposure to external factors, such as obesity, during development could affect the prostate cancer progression in adults. Our previous work demonstrated that exposure to a high fat/high sugar (HF/HS) diet during gestation and until weaning stimulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, High-Fat
Share to Maternal Exposure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Obesity

Share to Pregnancy

Share to Prostatic Neoplasms

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 28489892
DOI: 10.1371/journal.pone.0175764
PMCID: PMC5425180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exposure to maternal obesogenic diet worsens some but not all pre-cancer phenotypes in a murine genetic model of prostate cancer.PMID 28489892Read ↗

Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspringSemantic proximity Read ↗

Developmental Exposure to Endocrine Disrupting Chemicals Alters the Epigenome: Identification of Reprogrammed TargetsSemantic proximity Read ↗

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivitySemantic proximity Read ↗

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.Semantic proximity Read ↗

Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN.Semantic proximity Read ↗

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenSemantic proximity Read ↗

Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model.Semantic proximity Read ↗

Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational ImpactSemantic proximity Read ↗

Developmental exposure to estrogen alters differentiation and epigenetic programming in a human fetal prostate xenograft model.Semantic proximity Read ↗

Early-life estrogens and prostate cancer in an animal modelSemantic proximity Read ↗

IR-B deficiency and fatty acid dysregulation accelerate prostate cancer progression via PI3K/AKT signalingSemantic proximity Read ↗

The role of PIM1/PIM2 kinases in tumors of the male reproductive systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.