Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.

Hepatology (Baltimore, Md.) - 1 Aug 2008

Lee Sang Seop, Cha Eun-Young, Jung Hyun-Ju, Shon Ji-Hong, Kim Eun-Young, Yeo Chang-Woo, Shin Jae-Gook

Abstract excerpt

UNLABELLED: Hepatocyte nuclear factor-4 alpha (HNF4A) is an essential transcriptional regulator for many genes that are expressed preferentially in the liver. Among the important functions of the liver is drug metabolism in response to xenobiotic exposure. Recent studies have suggested that HNF4A regulates the expression of cytochrome P450 (CYP), including CYP2D6 and CYP3A4, which show large individual variations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Hepatocyte Nuclear Factor 4

Share to Linkage Disequilibrium

Share to Transcription, Genetic

Share to Transfection

Source

Identifiers

PMID: 18666237
DOI: 10.1002/hep.22396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.PMID 18666237Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicineSemantic proximity Read ↗

Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic DisordersSemantic proximity Read ↗

Role of HNF6 in liver homeostasis and pathophysiologySemantic proximity Read ↗

Human Hepatocyte Nuclear Factor 4 Isoforms Are Encoded by Distinct and Differentially Expressed GenesSemantic proximity Read ↗

HNF4α—role in drug metabolism and potential drug target?Semantic proximity Read ↗

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseasesSemantic proximity Read ↗

Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liverSemantic proximity Read ↗

HNF4α isoforms: the fraternal twin master regulators of liver functionSemantic proximity Read ↗

Variants in hepatocyte nuclear factor 4alpha gene promoter region and type 2 diabetes risk in Chinese.Semantic proximity Read ↗

Human hepatocyte nuclear factor-1 beta (HNF1B) 1968A/G polymorphism.Semantic proximity Read ↗

Shared regulation of UGT1A7 by hepatocyte nuclear factor (HNF) 1alpha and HNF4alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.