Article
[Concerning the significance of paraoxonase-1 and SR-B1 genes in atherosclerosis].
Revista espanola de cardiologia - 1 Feb 2006
Rodríguez Esparragón Francisco, Hernández Trujillo Yaridé, Macías Reyes Antonio, Hernández Ortega Enrique, Medina Alfonso, Rodríguez Pérez José C
Abstract excerpt
High-density lipoprotein (HDL) is an independent protective factor against cardiovascular disease. The enzyme paraoxonase-1 (PON-1) contributes to the anti-atherogenic effects of HDL. In vitro studies have demonstrated that paraoxonase's substrates are highly heterogeneous and that some contribute to the development of atherosclerotic lesions. The atheroprotective role of PON-1 was established in genetically...
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