Article
Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2005
Rodríguez-Esparragón Francisco, Rodríguez-Pérez José C, Hernández-Trujillo Yaridé, Macías-Reyes Antonio, Medina Alfonso, Caballero Araceli, Ferrario Carlos M
Abstract excerpt
OBJECTIVE: The antioxidant properties of high-density lipoprotein (HDL) have been attributed to paraoxonase (PON) enzyme activity. Human scavenger receptor class B type 1 (SR-BI; CD36 and lysosomal integral membrane protein-II analogous-1 [CLA-1]) plays a central role in HDL-mediated native and oxidized cholesteryl ester uptake. We tested for a significant contribution of common variant of these genes to coronary...
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