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Article

A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population.

BMC medical genetics - 15 Mar 2006

Núñez Concepción, López-Mejías Raquel, Martínez Alfonso, García-Rodríguez M Cruz, Fernández-Arquero Miguel, de la Concha Emilio G, Urcelay Elena

Abstract excerpt

BACKGROUND: The 1858C/T SNP of the PTPN22 gene has been associated with many autoimmune diseases, suggesting the existence of an inflammatory process common to all of them. We studied the association of that polymorphism with immunoglobulin A deficiency (IgAD) following a double approach: a case-control and a TDT study. METHODS: A total of 259 IgAD patients and 455 unrelated matched controls, and 128 families...

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Share to Autoimmune Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to IgA Deficiency

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 16539704
DOI: 10.1186/1471-2350-7-25
PMCID: PMC1431514

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population.PMID 16539704Read ↗

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