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Imaging cellular signals in the heart <i>in vivo</i> : Cardiac expression of the high-signal Ca <sup>2+</sup> indicator GCaMP2

13 Mar 2006

Abstract excerpt

Genetically encoded sensor proteins provide unique opportunities to advance the understanding of complex cellular interactions in physiologically relevant contexts; however, previously described sensors have proved to be of limited use to report cell signaling in vivo in mammals. Here, we describe an improved Ca(2+) sensor, GCaMP2, its inducible expression in the mouse heart, and its use to examine signaling in...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 16537386
DOI: 10.1073/pnas.0509378103

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