Article
Calcium Imaging in Pluripotent Stem Cell-Derived Cardiac Myocytes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016
Walter Anna, Šarić Tomo, Hescheler Jürgen, Papadopoulos Symeon
Abstract excerpt
The possibility to generate cardiomyocytes (CMs) from disease-specific induced pluripotent stem cells (iPSCs) is a powerful tool for the investigation of various cardiac diseases in vitro. The pathological course of various cardiac conditions, causatively heterogeneous, often converges into disturbed cellular Ca(2+) cycling. The gigantic Ca(2+) channel of the intracellular Ca(2+) store of CMs, the ryanodine...
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