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Article

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04.

The Journal of experimental medicine - 20 Mar 2006

Salomon Rachelle, Franks John, Govorkova Elena A, Ilyushina Natalia A, Yen Hui-Ling, Hulse-Post Diane J, Humberd Jennifer, Trichet Michel, Rehg Jerold E, Webby Richard J, Webster Robert G, Hoffmann Erich

Abstract excerpt

H5N1 influenza viruses transmitted from poultry to humans in Asia cause high mortality and pose a pandemic threat. Viral genes important for cell tropism and replication efficiency must be identified to elucidate and target virulence factors. We applied reverse genetics to generate H5N1 reassortants combining genes of lethal A/Vietnam/1203/04 (VN1203), a fatal human case isolate, and nonlethal...

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Source

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Identifiers

PMID: 16533883
DOI: 10.1084/jem.20051938
PMCID: PMC2118237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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