Article
Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks.
Journal of virology - 1 Aug 2007
Hulse-Post D J, Franks J, Boyd K, Salomon R, Hoffmann E, Yen H L, Webby R J, Walker D, Nguyen T D, Webster R G
Abstract excerpt
The highly pathogenic (HP) influenza viruses H5 and H7 are usually nonpathogenic in mallard ducks. However, the currently circulating HP H5N1 viruses acquired a different phenotype and are able to cause mortality in mallards. To establish the molecular basis of this phenotype, we cloned the human A/Vietnam/1203/04 (H5N1) influenza virus isolate that is highly pathogenic in ferrets, mice, and mallards and found it...
Topics
- Amino Acid Substitution
- Animals
- DNA Mutational Analysis
- Ducks
- Ferrets
- Genome, Viral
- Hemagglutinin Glycoproteins, Influenza Virus
- Influenza A Virus, H5N1 Subtype
- Influenza in Birds
- Mice
- Mutation
- RNA-Dependent RNA Polymerase
- Viral Proteins