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Article

Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks.

Journal of virology - 1 Aug 2007

Hulse-Post D J, Franks J, Boyd K, Salomon R, Hoffmann E, Yen H L, Webby R J, Walker D, Nguyen T D, Webster R G

Abstract excerpt

The highly pathogenic (HP) influenza viruses H5 and H7 are usually nonpathogenic in mallard ducks. However, the currently circulating HP H5N1 viruses acquired a different phenotype and are able to cause mortality in mallards. To establish the molecular basis of this phenotype, we cloned the human A/Vietnam/1203/04 (H5N1) influenza virus isolate that is highly pathogenic in ferrets, mice, and mallards and found it...

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Identifiers

PMID: 17553873
DOI: 10.1128/JVI.00435-07
PMCID: PMC1951362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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