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Article

Hemagglutinin-Neuraminidase Balance Influences the Virulence Phenotype of a Recombinant H5N3 Influenza A Virus Possessing a Polybasic HA0 Cleavage Site.

Journal of virology - 1 Nov 2015

Diederich Sandra, Berhane Yohannes, Embury-Hyatt Carissa, Hisanaga Tamiko, Handel Katherine, Cottam-Birt Colleen, Ranadheera Charlene, Kobasa Darwyn, Pasick John

Abstract excerpt

UNLABELLED: Although a polybasic HA0 cleavage site is considered the dominant virulence determinant for highly pathogenic avian influenza (HPAI) H5 and H7 viruses, naturally occurring virus isolates possessing a polybasic HA0 cleavage site have been identified that are low pathogenic in chickens. In this study, we generated a reassortant H5N3 virus that possessed the hemagglutinin (HA) gene from H5N1 HPAI...

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Identifiers

PMID: 26246579
DOI: 10.1128/JVI.01238-15
PMCID: PMC4621126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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