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Article

Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration.

The Journal of biological chemistry - 5 May 2006

Zhang Yongjun, Tu Yizeng, Gkretsi Vasiliki, Wu Chuanyue

Abstract excerpt

Cell migration is a complex process that is coordinately regulated by cell-matrix adhesion and actin cytoskeleton. We report here that migfilin, a recently identified component of cell-matrix adhesions, is a biphasic regulator of cell migration. Loss of migfilin impairs cell migration. Surprisingly, overexpression of migfilin also reduces cell migration. Molecularly, we have identified vasodilator-stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16531412
DOI: 10.1074/jbc.M512107200

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration.PMID 16531412Read ↗

Physical and functional association of migfilin with cell-cell adhesionsSemantic proximity Read ↗

Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.Semantic proximity Read ↗

Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells.Semantic proximity Read ↗

VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.Semantic proximity Read ↗

Maspin Regulates Endothelial Cell Adhesion and Migration through an Integrin Signaling PathwaySemantic proximity Read ↗

Loss of migfilin expression has no overt consequences on murine development and homeostasisSemantic proximity Read ↗

Tetraspanin CD9 links junctional adhesion molecule-A to αvβ3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling.Semantic proximity Read ↗

VASP is upregulated by WDR5-MYC nexus and promotes cell migration in breast cancerSemantic proximity Read ↗

Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization.Semantic proximity Read ↗

Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motilitySemantic proximity Read ↗

The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction.Semantic proximity Read ↗

Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.Semantic proximity Read ↗

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