Article
Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.
Cancer research - 1 Aug 2004
Basile John R, Barac Ana, Zhu Tianqing, Guan Kun-Liang, Gutkind J Silvio
Abstract excerpt
The semaphorins are a large family of secreted and cell surface proteins that provide attractive and repulsive cues for axon guidance during neuronal development. Semaphorins share a conserved NH(2)-terminal Sema domain with their receptors, the plexins, which mediate neuronal cell adhesion, axon guidance, and maintenance of established neuronal pathways in the adult. Both semaphorins and plexins share structural...
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