Article
Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.
Molecular biology of the cell - 1 Jul 2002
Loureiro Joseph J, Rubinson Douglas A, Bear James E, Baltus Gretchen A, Kwiatkowski Adam V, Gertler Frank B
Abstract excerpt
The Ena/vasodilator-stimulated phosphoprotein (VASP) protein family is implicated in the regulation of a number of actin-based cellular processes, including lamellipodial protrusion necessary for whole cell translocation. A growing body of evidence derived largely from in vitro biochemical experiments using purified proteins, cell-free extracts, and pathogen motility has begun to suggest various mechanistic roles...
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