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Article

Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype.

Glia - 15 Aug 2006

Tawfik Vivianne L, Lacroix-Fralish Michael L, Bercury Kathryn K, Nutile-McMenemy Nancy, Harris Brent T, Deleo Joyce A

Abstract excerpt

Reactive astrocytes display decreased glutamate transporters, such as GLT-1, and as a result synaptic glutamate clearance is impaired. In addition, these activated astrocytes are immunocompetent and release algesic mediators that can sensitize neurons in the spinal cord. Currently, we evaluated the effect of propentofylline (PPF), an experimental antiallodynic agent, on the phenotype and glutamate transporter...

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Source

Identifiers

PMID: 16819765
DOI: 10.1002/glia.20365

Genes

CCL2
CXCL2
MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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