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Article

Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.

Molecular and cellular biology - 1 Jul 2002

Oliver Carey J, Terry-Lorenzo Ryan T, Elliott Elizabeth, Bloomer Wendy A Christensen, Li Shi, Brautigan David L, Colbran Roger J, Shenolikar Shirish

Abstract excerpt

Neurabin I, a neuronal actin-binding protein, binds protein phosphatase 1 (PP1) and p70 ribosomal S6 protein kinase (p70S6K), both proteins implicated in cytoskeletal dynamics. We expressed wild-type and mutant neurabins fused to green fluorescent protein in Cos7, HEK293, and hippocampal neurons. Biochemical and cellular studies showed that an N-terminal F-actin-binding domain dictated neurabin I localization at...

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Identifiers

PMID: 12052877
DOI: 10.1128/MCB.22.13.4690-4701.2002
PMCID: PMC133892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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