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Article

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1

8 Mar 2006

Abstract excerpt

Intracellular accumulation of mutant Huntingtin with expanded polyglutamine provides a context-dependent cytotoxicity critical for the pathogenesis of Huntington disease (Everett, C. M., and Wood, N. W. (2004) Brain 127, 2385-2405). Here we demonstrate that the accumulation of mutant Huntingtin is highly sensitive to the expression of beclin 1, a gene essential for autophagy. Moreover, we show that the...

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Identifiers

PMID: 16522639
DOI: 10.1074/jbc.m600364200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1PMID 16522639Read ↗

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