Article
Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.
BMC genetics - 6 Mar 2006
Sentinelli Federica, Romeo Stefano, Barbetti Fabrizio, Berni Andrea, Filippi Emanuela, Fanelli Marzia, Fallarino Mara, Baroni Marco G
Abstract excerpt
BACKGROUND: Among the possible candidate genes for atherosclerosis experimental data point towards the longevity gene p66Shc. The p66Shc gene determines an increase of intracellular reactive oxygen species (ROS), affecting the rate of oxidative damage to nucleic acids. Knock-out p66Shc-/- mice show reduction of systemic oxidative stress, as well as of plasma LDL oxidation, and reduced atherogenic lesions. Thus,...
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