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Article

p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.

Endothelium : journal of endothelial cell research - 1 Jan 2000

Martin-Padura Ines, de Nigris Filomena, Migliaccio Enrica, Mansueto Gelsomina, Minardi Simone, Rienzo Monica, Lerman Lilach O, Stendardo Massimo, Giorgio Marco, De Rosa Gaetano, Pelicci Pier Giuseppe, Napoli Claudio

Abstract excerpt

Previous studies showed that p66(Shc-/-) mice on a very-high-fat diet (HFD) had reduced oxidative stress, foam cell, and early atherosclerotic lesion formation. Here, the authors have used hypercholesterolemic apolipoprotein E (ApoE(-/-)) mice to investigate the role of p66Shc deletion in advance...

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Source

Identifiers

PMID: 19065319
DOI: 10.1080/10623320802487791

Genes

ACAT1
THBS1
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19065319-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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