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Article

The p66Shc knockout mice are short lived under natural condition

15 Nov 2011

Abstract excerpt

Deletion of the p66(Shc) gene results in lean and healthy mice, retards aging, and protects from aging-associated diseases, raising the question of why p66(Shc) has been selected, and what is its physiological role. We have investigated survival and reproduction of p66(Shc)-/- mice in a population living in a large outdoor enclosure for a year, subjected to food competition and exposed to winter temperatures....

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PMID: 22081964
DOI: 10.1111/j.1474-9726.2011.00770.x

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