Article
Variation in the SHC1 gene and longevity in humans.
Experimental gerontology - 1 Feb 2004
Mooijaart Simon P, van Heemst Diana, Schreuder Jeroen, van Gerwen Suzan, Beekman Marian, Brandt Bernd W, Eline Slagboom P, Westendorp Rudi G J
Abstract excerpt
Mice in which the p66(SHC) specific region of the SHC gene is deleted live 30% longer without apparent disease. These mice have lower levels of oxidative stress and apoptosis, both of which have been linked to old age survival in man. This makes SHC1 an important candidate gene for longevity in humans. We found no variations in the p66 specific region of the SHC1 gene in 30 young and 30 extreme long-lived...
Topics
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Adult
- Aged
- Aged, 80 and over
- Female
- Follow-Up Studies
- Gene Frequency
- Genetic Variation
- Humans
- Longevity
- Male
- Mortality
- Netherlands
- Polymorphism, Genetic