Article
Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9.
Genes, chromosomes & cancer - 1 Jun 2006
Sindt Audrey, Deau Benedicte, Brahim Wajih, Staal Anne, Visanica Sorin, Villarese Patrick, Rault Jean-Philippe, Macintyre Elizabeth, Delabesse Eric
Abstract excerpt
The t(9;22)(q34;q11) translocation occurs in chronic myeloid leukemia (CML) and adult B-cell acute lymphoblastic leukemia (ALL), leading to fusion of BCR to ABL1 and constitutive activation of ABL1 tyrosine kinase activity. The main BCR-ABL1 breakpoints result in P190 BCR-ABL1 or P210 BCR-ABL1 fusion proteins. The latter is found in almost all cases of CML and in one third of the cases of t(9;22)-positive adult...
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