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Article

Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: A series of 10 cases of a clinically aggressive neoplasm.

American journal of hematology - 1 Jun 2017

Salem Alireza, Loghavi Sanam, Tang Guilin, Huh Yang O, Jabbour Elias J, Kantarjian Hagop, Wang Wei, Hu Shimin, Luthra Rajyalakshmi, Medeiros L Jeffrey, Khoury Joseph D

Abstract excerpt

Chronic myeloid leukemia (CML) is defined by the presence of t(9;22)(q34;q11.2)/BCR-ABL1. Additional chromosomal abnormalities confer an adverse prognosis and are particularly common in the blast phase of CML (CML-BP). CBFB rearrangement, particularly CBFB-MYH11 fusion resulting from inv(16)(p13.1q22) or t(16;16)(p13.1;q22), is an acute myeloid leukemia (AML)-defining alteration that is associated with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fusion Proteins, bcr-abl

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Source

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Identifiers

PMID: 28253536
DOI: 10.1002/ajh.24710
PMCID: PMC5860811

Genes

CBFB
ABL1
BCR
MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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