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Article

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

1 Jan 2014

Abstract excerpt

BACKGROUND: The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes downstream of MLL-AF9 (alias MLL-MLLT3) which could assist to develop new targeted therapies for such leukemia with unfavorable prognosis. METHODS: In the AML cell line THP1 which harbors this...

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PMID: 24517546
DOI: 10.1186/1476-4598-13-27

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