Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

doi:10.1038/sj.leu.2403236

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Article

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Leukemia - 1 Feb 2004

Drexler H G, Quentmeier H, MacLeod R A F

Abstract excerpt

Human tumor cell lines are powerful tools for investigating basic and applied aspects of cell biology. Leukemia-lymphoma cell lines have been instrumental in the cytogenetic and molecular analysis of recurring chromosome rearrangements, notably translocations and inversions, thus illuminating the pathogenesis of hematological malignancy. Chromosomal translocations targeting the MLL gene at 11q23 have come to...

Topics

Cell Line, Tumor
Chromosomes, Human, Pair 11
DNA-Binding Proteins
Gene Amplification
Histone-Lysine N-Methyltransferase
Humans
Leukemia
Mutation
Myeloid-Lymphoid Leukemia Protein
Oncogene Proteins, Fusion
Proto-Oncogenes
Tandem Repeat Sequences
Transcription Factors
Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 14671638
DOI: 10.1038/sj.leu.2403236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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