Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

Cancer research - 1 Sept 1991

Hinds M, Deisseroth K, Mayes J, Altschuler E, Jansen R, Ledley F D, Zwelling L A

Abstract excerpt

HL-60/AMSA is a human leukemia cell line that is 50- to 100-fold more resistant to the cytotoxic actions of the topoisomerase II-reactive intercalator amsacrine than is its drug-sensitive HL-60 parent line. Previously, we have shown that the topoisomerase II from HL-60/AMSA is also resistant to inhibition by amsacrine and other intercalating agents. We therefore sought the molecular basis for the resistance of...

Topics

Amino Acid Sequence
Amsacrine
DNA Topoisomerases, Type II
DNA, Neoplasm
Drug Resistance
Genes
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1651812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1651812-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.PMID 1651812Read ↗

Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha.Semantic proximity Read ↗

A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance.Semantic proximity Read ↗

Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine.Semantic proximity Read ↗

DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.Semantic proximity Read ↗

Megabase pair deletions in mutant mammalian cells following exposure to amsacrine, an inhibitor of DNA topoisomerase II.Semantic proximity Read ↗

Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines.Semantic proximity Read ↗

Mechanistic studies of amsacrine-resistant derivatives of DNA topoisomerase II. Implications in resistance to multiple antitumor drugs targeting the enzyme.Semantic proximity Read ↗

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.Semantic proximity Read ↗

Mutations in the gyrB domain of eukaryotic topoisomerase II can lead to partially dominant resistance to etoposide and amsacrine.Semantic proximity Read ↗

Mutation in the ligand-binding domain of the retinoic acid receptor alpha in HL-60 leukemic cells resistant to retinoic acid and with increased sensitivity to vitamin D3 analogs.Semantic proximity Read ↗

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line.Semantic proximity Read ↗

Characterisation of adriamycin- and amsacrine-resistant human leukaemic T cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.