Article
A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance.
Cancer communications - 1 Jan 1990
Zwelling L A, Mayes J, Deisseroth K, Hinds M, Grant G, Pathak S, Ledley F D, Vyas R, Hittelman W
Abstract excerpt
In previous studies we used Southern blotting to examine the topoisomerase II locus (on chromosome 17) in human leukemia cell lines and noted a difference in the XmnI restriction endonuclease digestion pattern between an m-AMSA-resistant line and its m-AMSA-sensitive parent line (Zwelling, L. A.;...
Topics
- Alleles
- Amsacrine
- Chromosomes, Human, Pair 17
- DNA
- DNA Topoisomerases, Type II
- Drug Resistance
- Genetic Variation
- Humans
- Leukemia, Experimental
- Leukemia, Myeloid
- Polymorphism, Restriction Fragment Length
- Tumor Cells, Cultured