Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha.

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Article

Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha.

Cancer research - 1 Dec 1998

Herzog C E, Holmes K A, Tuschong L M, Ganapathi R, Zwelling L A

Abstract excerpt

Numerous chemotherapeutic agents act via stabilization of a topoisomerase (topo) II-DNA complex. HL-60/AMSA, a human leukemia cell line, is resistant to intercalator-mediated DNA complex formation and cytotoxicity. HL-60/AMSA contains a mutant form of topo IIalpha that was thought to explain this...

Topics

Amsacrine
Antigens, Neoplasm
Antineoplastic Agents
Blotting, Northern
Blotting, Southern
DNA Topoisomerases, Type II
DNA-Binding Proteins
Drug Resistance, Neoplasm
HL-60 Cells
Humans
Immunoblotting
Isoenzymes
Mutation
Phenotype
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 9850052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9850052-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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