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Article

Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis.

Blood - 1 Jun 2003

Kim Moo-Kyung, Huang Zhen-Yu, Hwang Pyoung-Han, Jones Brian A, Sato Norihito, Hunter Sharon, Kim-Han Tai-Hee, Worth Randall G, Indik Zena K, Schreiber Alan D

Abstract excerpt

We constructed chimeric receptors to dissect the role of the transmembrane (TM) domain in cell surface expression of and phagocytosis by the gamma chain-dependent Fcgamma receptors FcgammaRIIIA and FcgammaRI. FcgammaR chimeras containing the TM and cytoplasmic (CY) domains of the gamma chain were expressed on the cell surface and mediated an efficient phagocytic signal. In contrast, chimeras containing the...

Topics

Amino Acid Sequence
Animals
COS Cells
Erythrocytes
Mutation
Phagocytosis
Protein Structure, Tertiary
Receptors, Cell Surface
Receptors, IgG
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sheep

Transfection

Source

Identifiers

PMID: 12756162
DOI: 10.1182/blood.V101.11.4479

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