FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.

doi:10.4049/jimmunol.178.6.3973

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2007

Wu Jianming, Ji Chuanyi, Xie Fenglong, Langefeld Carl D, Qian Kun, Gibson Andrew W, Edberg Jeffrey C, Kimberly Robert P

Abstract excerpt

The human IgA FcR (FcalphaRI; CD89) mediates a variety of immune system functions including degranulation, endocytosis, phagocytosis, cytokine synthesis, and cytokine release. We have identified a common, nonsynonymous, single nucleotide polymorphism (SNP) in the coding region of CD89 (844A-->G) (rs16986050), which changes codon 248 from AGC (Ser(248)) to GGC (Gly(248)) in the cytoplasmic domain of the receptor....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Degranulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocytosis

Share to Immunoglobulin A

Share to Interleukin-6

Share to Lupus Erythematosus, Systemic

Share to Neutrophils

Share to Phagocytosis

Share to Receptors, Fc

Source

Open in PubMed

Identifiers

PMID: 17339498
DOI: 10.4049/jimmunol.178.6.3973

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.PMID 17339498Read ↗

Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.Semantic proximity Read ↗

A novel polymorphism in the cytoplasmic region of the human immunoglobulin A Fc receptor gene.Semantic proximity Read ↗

Multiple transcripts of human IgA Fc receptor CD89 in neutrophils, eosinophils and the monocyte-like cell line THP-1.Semantic proximity Read ↗

Functional and clinical consequences of Fc receptor polymorphic and copy number variants.Semantic proximity Read ↗

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.Semantic proximity Read ↗

Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.Semantic proximity Read ↗

A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis.Semantic proximity Read ↗

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.Semantic proximity Read ↗

Single nucleotidic polymorphism 844 A->G of FCAR is not associated with IgA nephropathy in Caucasians.Semantic proximity Read ↗

The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1.Semantic proximity Read ↗

Immune complex formation in IgA nephropathy: CD89 a 'saint' or a 'sinner'?Semantic proximity Read ↗

Association of FcεRIβ polymorphisms with risk of asthma and allergic rhinitis: evidence based on 29 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.