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Article

Superior protective and therapeutic effects of IL-12 and IL-18 gene-transduced dendritic neuroblastoma fusion cells on liver metastasis of murine neuroblastoma.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006

Iinuma Hisae, Okinaga Kota, Fukushima Ryoji, Inaba Tsuyoshi, Iwasaki Kota, Okinaga Akira, Takahashi Ichiro, Kaneko Michio

Abstract excerpt

Fusion vaccine of dendritic cells (DCs) and tumor cells has the advantage of inducing an immune response against multiple tumor Ags, including unknown tumor Ags. Using the liver metastasis model of C1300 neuroblastoma cells, we assessed the protective and therapeutic effects of fusion cells transduced with the IL-12 gene and/or the IL-18 gene. Improving the fusion method by combining polyethylene glycol and...

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Identifiers

PMID: 16517714
DOI: 10.4049/jimmunol.176.6.3461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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