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Article

C3d adjuvant effects are mediated through the activation of C3d-specific autoreactive T cells.

Immunology and cell biology - 1 Feb 2015

De Groot Anne S, Ross Ted M, Levitz Lauren, Messitt Timothy J, Tassone Ryan, Boyle Christine M, Vincelli Amber J, Moise Leonard, Martin William, Knopf Paul M

Abstract excerpt

Complement fragment C3d covalently attached to antigens enhances immune responses, particularly for antigens lacking T-cell epitopes. Enhancement has been attributed to receptor cross-linking between complement receptor CR2 (CD21) and polysaccharide antigen to surface IgM on naïve B cells. Paradoxically, C3d has still been shown to increase immune responses in CD21 knockout mice, suggesting that an auxiliary...

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Identifiers

PMID: 25385064
DOI: 10.1038/icb.2014.89
PMCID: PMC4323994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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