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Article

Rare complement factor H variant associated with age-related macular degeneration in the Amish.

Investigative ophthalmology & visual science - 6 Jun 2014

Hoffman Joshua D, Cooke Bailey Jessica N, D'Aoust Laura, Cade William, Ayala-Haedo Juan, Fuzzell Denise, Laux Renee, Adams Larry D, Reinhart-Mercer Lori, Caywood Laura, Whitehead-Gay Patrice, Agarwal Anita, Wang Gaofeng, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

PURPOSE: Age-related macular degeneration is the leading cause of blindness among the adult population in the developed world. To further the understanding of this disease, we have studied the genetically isolated Amish population of Ohio and Indiana. METHODS: Cumulative genetic risk scores were calculated using the 19 known allelic associations. Exome sequencing was performed in three members of a small Amish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Macular Degeneration

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Source

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Identifiers

PMID: 24906858
DOI: 10.1167/iovs.13-13684
PMCID: PMC4107619

Genes

CFH
ARMS2
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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