Article
Effective treatment of human breast tumor in a mouse xenograft model with herpes simplex virus type 1 specifying the NV1020 genomic deletion and the gBsyn3 syncytial mutation enabling high viral replication and spread in breast cancer cells.
Human gene therapy - 1 May 2007
Israyelyan Anna H, Melancon Jeffrey M, Lomax Larry G, Sehgal Inder, Leuschner Carola, Kearney Michael T, Chouljenko Vladimir N, Baghian Abolghasem, Kousoulas Konstantin G
Abstract excerpt
A new oncolytic and fusogenic herpes simplex virus type 1 (HSV-1) was constructed on the basis of the wildtype HSV-1(F) strain. To provide for safety and tumor selectivity, the virus carried a large deletion including one of the two alpha4, gamma(1)34.5, alpha0 genes and the latency-associated tr...
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