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Article

Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA.

Cancer research - 15 Sept 2009

Kadota Mitsutaka, Sato Misako, Duncan Beverly, Ooshima Akira, Yang Howard H, Diaz-Meyer Natacha, Gere Sheryl, Kageyama Shun-Ichiro, Fukuoka Junya, Nagata Takuya, Tsukada Kazuhiro, Dunn Barbara K, Wakefield Lalage M, Lee Maxwell P

Abstract excerpt

To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes include the well-known oncogenes ERBB2, FGFR1, MYC, CCND1, and PIK3CA, whereas other known oncogenes...

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Source

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Identifiers

PMID: 19706770
DOI: 10.1158/0008-5472.CAN-09-0064
PMCID: PMC2745517

Genes

IRX2
ASPH
BRD4
CCND1
CCND2
EGFR
ERBB2
FGFR1
FGFR2
IRAK4
MYC
NOTCH3
POLD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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