Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Mar 2006

Katz David A, Carr Robert, Grimm David R, Xiong Hao, Holley-Shanks Rhonda, Mueller Toby, Leake Brenda, Wang Qiang, Han Lixin, Wang Perry G, Edeki Timi, Sahelijo Leonardo, Doan Thao, Allen Andrew, Spear Brian B, Kim Richard B

Abstract excerpt

OBJECTIVE: Our objective was to learn whether genetic polymorphisms of metabolic enzymes or transport proteins provide a mechanistic understanding of the in vivo disposition of atrasentan, a selective endothelin A receptor antagonist. METHODS: Atrasentan uptake was measured in HeLa cells transfected to express major alleles of organic anion transporting polypeptide 1B1 (OATP1B1). The results were used to classify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to HeLa Cells

Share to Liver-Specific Organic Anion Transporter 1

Share to Organic Anion Transporters

Share to Pyrrolidines

Share to Transfection

Source

Identifiers

PMID: 16513443
DOI: 10.1016/j.clpt.2005.11.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics.PMID 16513443Read ↗

Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms.Semantic proximity Read ↗

Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.Semantic proximity Read ↗

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.Semantic proximity Read ↗

Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants.Semantic proximity Read ↗

Pharmacogenomics of the OATP and OAT families.Semantic proximity Read ↗

Impact of OATP transporters on pharmacokinetics.Semantic proximity Read ↗

Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.Semantic proximity Read ↗

Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of DrugsSemantic proximity Read ↗

Impact of genetic variation in OATP transporters to drug disposition and response.Semantic proximity Read ↗

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.Semantic proximity Read ↗

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans.Semantic proximity Read ↗

A UGT2B10 splicing polymorphism common in african populations may greatly increase drug exposure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.