Article
Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.
The Journal of biological chemistry - 15 Aug 1991
Nagayama Y, Russo D, Wadsworth H L, Chazenbalk G D, Rapoport B
Abstract excerpt
Our previous studies involving chimeric thyrotropin-lutropin/choriogonadotropin (TSH-LH/CG) receptors suggest that multiple segments spanning the entire extracellular domain of the human TSH receptor contribute to the TSH binding site. Nevertheless, the mid-region (segment C, amino acid residues...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Binding, Competitive
- Chimera
- Cricetinae
- Cricetulus
- Cyclic AMP
- Humans
- Ligands
- Molecular Sequence Data
- Mutation
- Plasmids
- Rats
- Receptors, LH
- Receptors, Thyrotropin
- Thyrotropin
- Transfection