Article
Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 1996
Bhowmick N, Huang J, Puett D, Isaacs N W, Lapthorn A J
Abstract excerpt
The LH/CG receptor (LH/CG-R) belongs to the family of glycoprotein hormone G protein-coupled receptors. The extracellular domain of LH/CG-R is associated with high ligand-binding affinity and contains leucine-rich repeats (LRRs). With the goal of identifying essential amino acid residues involved...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- COS Cells
- Chorionic Gonadotropin
- Conserved Sequence
- DNA, Complementary
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation