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Characterization of the ‘pristinamycin supercluster’ of <i>Streptomyces pristinaespiralis</i>

15 Oct 2010

Abstract excerpt

Pristinamycin, produced by Streptomyces pristinaespiralis Pr11, is a streptogramin antibiotic consisting of two chemically unrelated compounds, pristinamycin I and pristinamycin II. The semi-synthetic derivatives of these compounds are used in human medicine as therapeutic agents against methicillin-resistant Staphylococcus aureus strains. Only the partial sequence of the pristinamycin biosynthetic gene cluster...

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PMID: 21342465
DOI: 10.1111/j.1751-7915.2010.00213.x

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