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Article

Improving the N-terminal diversity of sansanmycin through mutasynthesis.

Microbial cell factories - 6 May 2016

Shi Yuanyuan, Jiang Zhibo, Lei Xuan, Zhang Ningning, Cai Qiang, Li Qinglian, Wang Lifei, Si Shuyi, Xie Yunying, Hong Bin

Abstract excerpt

BACKGROUND: Sansanmycins are uridyl peptide antibiotics (UPAs), which are inhibitors of translocase I (MraY) and block the bacterial cell wall biosynthesis. They have good antibacterial activity against Pseudomonas aeruginosa and Mycobacterium tuberculosis strains. The biosynthetic gene cluster of sansanmycins has been characterized and the main biosynthetic pathway elucidated according to that of pacidamycins...

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Identifiers

PMID: 27154005
DOI: 10.1186/s12934-016-0471-1
PMCID: PMC4858918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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