Article
Identification of deletion mutations and three new genes at the familial polyposis locus.
Cell - 9 Aug 1991
Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W, Groden J, Stevens J, Spirio L, Robertson M
Abstract excerpt
Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal...
Topics
- Adenomatous Polyposis Coli
- Amino Acid Sequence
- Base Sequence
- Chromosome Deletion
- Cloning, Molecular
- Colonic Neoplasms
- DNA
- Humans
- Molecular Sequence Data
- Mutation
- Pedigree