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Article

Overexpression of <i>Drosophila mitoferrin</i> in l(2)mbn cells results in dysregulation of Fer1HCH expression

20 May 2009

Abstract excerpt

Mrs3p and Mrs4p (Mrs3/4p) are yeast mitochondrial iron carrier proteins that play important roles in ISC (iron-sulphur cluster) and haem biosynthesis. At low iron conditions, mitochondrial and cytoplasmic ISC protein maturation is correlated with MRS3/4 expression. Zebrafish mitoferrin1 (mfrn1), one of two MRS3/4 orthologues, is essential for erythropoiesis, but little is known about the ubiquitously expressed...

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PMID: 19453295
DOI: 10.1042/bj20082231

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