Article
Sfxn1 is essential for erythrocyte maturation via facilitating hemoglobin production in zebrafish.
Biochimica et biophysica acta. Molecular basis of disease - 1 May 2021
Bao Binghao, An Wenbin, Lu Qunwei, Wang Yaqin, Lu Zhichao, Tu Jiayi, Zhang Heng, Duan Yongjuan, Yuan Weiping, Zhu Xiaofan, Jia Haibo
Abstract excerpt
Previous reports revealed that mutation of mitochondrial inner-membrane located protein SFXN1 led to pleiotropic hematological and skeletal defects in mice, associated with the presence of hypochromic erythroid cell, iron overload in mitochondrion of erythroblast and the development of sideroblastic anemia (SA). However, the potential role of sfxn1 during erythrocyte differentiation and the development of anemia,...
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